One of the acceptable methods to quantify the level of inherent safety is based on the inherent safety index. This paper reviewed presently available techniques for quantification of inherent safety level in a design and addresses the shortcoming of current techniques by proposing direct integration of a process simulator with an inherent safety index. This integrated index, called the Inherent Safety Index Module (ISIM), is one of the modules developed in a newly proposed framework to determine inherent safety levels in the preliminary design stage. This framework is an enhancement of the framework developed earlier by Mohd Shariff et al. (2006). This new framework allowed process information from a process design simulator to be extracted and analysed for the determination of the Inherent Safety Level (ISL), consequences and probability of unwanted incidences. The availability of such information at an early stage of design will help process designers to obtain ISL that will assist in producing safer designs by the application of inherent safety principles in a more efficient and cost effective manner. This paper also discussed the overall concept of the proposed framework to produce an inherent safety tool. A case study was provided to illustrate the benefit of having an inherent safety index known to process designers during the preliminary design stage. With the right information, modifications to process conditions can be carried out and this will likely produce a safer process plant.